706-4 Preconditioning Shortens Action Potential Duration and Lowers Ventricular Fibrillation Threshold in Pig Hearts
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چکیده
منابع مشابه
Two types of ventricular fibrillation in isolated rabbit hearts: importance of excitability and action potential duration restitution.
BACKGROUND The combined effects of excitability and action potential duration (APD) restitution on wavefront dynamics remain unclear. METHODS AND RESULTS We used optical mapping techniques to study Langendorff-perfused rabbit hearts. In protocol IA (n=10), D600 at increasing concentrations was infused during ventricular fibrillation (VF). With concentration increased to 0.5 mg/L, fast VF (dom...
متن کاملVentricular fibrillation in preconditioned pig hearts: role of KATP
Rioufol, Gilles, Michel Ovize, Joseph Loufoua, Calin Pop, Xavier André-Fouët, and Yves Minaire. Ventricular fibrillation in preconditioned pig hearts: role of KATP 1 channels. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H2804– H2810, 1997.—ATP-dependent potassium (KATP 1 ) channels play a role in the infarct size-limiting effect of preconditioning in pigs. We previously demonstrated that pre...
متن کاملHuman ventricular action potential duration restitution.
. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden death: a distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 1992;20:1391–6. . Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 1999;100:1660–6. . Breithardt G, Cain ME, El-Sheri...
متن کاملDynamic restitution of action potential duration during electrical alternans and ventricular fibrillation.
The restitution kinetics of action potential duration (APD) were investigated in paced canine Purkinje fibers (P; n = 9) and endocardial muscle (M; n = 9), in isolated, perfused canine left ventricles during ventricular fibrillation (VF; n = 4), and in endocardial muscle paced at VF cycle lengths (simulated VF; n = 4). Restitution was assessed with the use of two protocols: delivery of a single...
متن کاملRole of maximum rate of depolarization in predicting action potential duration during ventricular fibrillation.
During ventricular fibrillation (VF) only 39% of the variation in action potential duration (APD) is accounted for by the previous diastolic interval [DI((n-1))], i.e., restitution, and the previous APD [APD((n-1))], i.e., memory. We tested the hypothesis that a characteristic of the AP upstroke, the maximum rate of depolarization (V(max)), also helps account for its APD. A floating microelectr...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1995
ISSN: 0735-1097
DOI: 10.1016/0735-1097(95)91635-b